Similarly, Dox-induced IRAK1 knockdown impaired both the primary and secondary mammosphere formation in IRAK1 high-expressing TNBC cell lines, but not MDA231 cells, indicating a role of IRAK1 in both tumour-initiating and self-renewal capacity (Fig. 2f and Supplementary Fig. 1G). The gene discussed is IRAK1; the disease is neoplasm.