Several endogenous proteins have been suggested as potential biomarkers of tumor hypoxia, including hypoxia-inducible factor-1α (HIF-1α, the α subunit of the transcription factor HIF-1) and downstream target genes of HIF-1 such as vascular endothelial growth factor-A (VEGF-A), glucose transporter-1, and carbonic anhydrase IX (CAIX) [17–20]. The gene discussed is VEGFA; the disease is neoplasm.