HIF1A and neoplasm: It was hypothesized that micro regional heterogeneity would be observed; that 64Cu-ATSM and 18F-FDG would show varying degrees of overlap and correlation; that 64Cu-ATSM would correlate positively with gene expression of endogenous markers of hypoxia, glycolysis and angiogenesis due to the important function of HIF-1α in their regulation; that 18F-FDG would correlate with gene expression of genes involved in glycolysis; and lastly that 64Cu-ATSM and 18F-FDG also to some extent would reflect tumour proliferation.