Possible explanations for this difference in results may be: 1) that tumour pieces used for gene expression analysis and IHC originated from different areas of the tumour; 2) that post transcriptional or translational changes happen between the mRNA measured during qPCR and the protein measured during IHC; 3) that Ki-67 IHC staining was too scarce and homogenous; 4) the limitations associated with comparing Ki-67 IHC and AR images having very different image resolutions. Here, MKI67 is linked to neoplasm.