To evaluate the significance of LOX in prostate cancer, a TMA including tumor tissue and tumor-adjacent non-malignant prostate tissue (tissue cores were sampled at random distances from tumor tissue) from 351 prostate cancer patients with long follow-up was analyzed and scored by LOX immunohistochemistry in four different compartments; non-malignant prostate epithelium (TINT epithelium), non-malignant prostate stroma (TINT stroma), prostate tumor epithelium and prostate tumor stroma. The gene discussed is LOX; the disease is Familial prostate cancer.