Interestingly, Berghoff et al. observed a correlation of PD-L1 expression with molecular glioblastoma subtypes [44] with a higher rate of PD-L1 high expressors among mesenchymal glioblastomas and lower rates in glioma-CpG island methylator phenotype (G-CIMP) and proneural glioblastomas [10]. Here, CD274 is linked to central nervous system cancer.