In 2006, one study on a single Mexican-American family [21] found a novel diabetes risk mutation in ADRB3 using linkage analysis; more recently, a GWAS study conducted on Mexican-Americans in Starr County, Texas[9] found three novel risk genes, TOMM7, HNT and PARD3B. However, it is largely unknown how much population heterogeneity in diabetes prevalence can be explained by these loci. This evidence concerns the gene PARD3B and diabetes mellitus.