Inhibition of Mcl-1 with epigallocatechin-3-gallate (EGCG), a potent antioxidant, antiinflammatory and antioncogenic compound, markedly inhibited the accumulation of p-Akt and the nuclear translocation and DNA binding activity of NF-κB p65 in TNF-α -stimulated RA synovial fibroblasts [148]. This evidence concerns the gene NFKB1 and rheumatoid arthritis.