Thus for instance, STAT3 is a direct transcription factor for the sphingosine-1-phosphate receptor 1 (S1PR1) gene promoter, a G-protein-coupled receptors for sphingosine-1-phosphate (S1P), a biologically active metabolite of sphingolipid with critical roles in lymphocyte egress and chemotaxis, cell proliferation, survival, and tumor angiogenesis and metastasis [63]. Here, STAT3 is linked to neoplasm.