PRKDC and familial pancreatic carcinoma: Of note, human epithelial cells derived from pancreas carcinoma (MiaPaCa) exposed to 17-DMAG show the reduction of (i) the ErbB1 activity; (ii) the IR-induced interaction between ErbB1 and DNA-PK; and (iii) the IR-induced activation of DNA-PK, compromising the DSBs repair [60].