NHERF2 and deafness: For the subnuclear localized domains; however, three out of six randomly-selected domains, including the deafness, autosomal recessive 31 PDZ1 (DFNB31_1), the sodium-hydrogen exchange regulatory cofactor NHERF2 PDZ1 (SLC9A3R2_1) and the Syntrophin, Gamma 1 PDZ domain (SNTG1) showed PI(4,5)P dependency, and displayed a more diffuse nuclear or cytoplasmic localization upon membrane lipid modifying treatments.