TFPI2 and neoplasm: Similarly, the TFPI1 homolog, TFPI2, is also considered a tumor suppressor [47] due to several lines of evidence: its promoter has been shown repeatedly to be hypermethylated and silenced in cancer cell lines compared to normal cells, it is silenced in multiple cancer cell lines and patient samples, and its in vitro knockdown resulted in cancer cell migration and invasion [48,49,50,51,52,53].