TFPI and colon adenocarcinoma: TFPI1 overexpression is not specific to the MCF7 cell lines that have undergone selection for resistance to DOX, as we have demonstrated that TFPI1 protein levels were elevated in all MDR cells tested, including human K562 myelogenous leukemia cells and human colon adenocarcinoma Colo201 cells we selected for DOX resistance, and rat glioblastoma treatment sensitive and resistant C6 and F98 cells, respectively [64].