These data extend previous findings suggesting that RhoA ADP-ribosyltransferase activity promotes the metastatic dissemination of S. aureus via a hematogenous route in mice [15,21] and that in humans, edin-positive strains of S. aureus are found in deep seated infections, such as high-grade diabetic foot ulcerations associated with bacteremia [6,22]. The gene discussed is RHOA; the disease is diabetic foot.