A large, multicenter genome-wide association study (GWAS) in PSP confirmed the role of H1 MAPT haplotype as a major risk factor; in addition several new risk loci were identified: STX6 (coding for syntaxin 6), EIF2AK3 (encoding PERK) and MOBP (coding for myelin-associated oligodendrocyte basic protein) on chromosomes 1, 2 and 3 respectively [152]. The gene discussed is MOBP; the disease is supranuclear palsy, progressive, 1.