TP53 and amebiasis: Many of these pathways were reported to be induced by SM in the previous studies, such as the MAPK signaling pathway [32,33,34,35,36], pathways in cancer [32], antigen processing and presentation [37], cell adhesion molecules (CAMs) [36,37], cell cycle [32], the p53 signaling pathway [32,36], vascular smooth muscle contraction [32], progesterone-mediated oocyte maturation [32], hematopoietic cell lineage [32,36], neuroactive ligand-receptor interaction [36], purine metabolism [32,36], chemokine signaling pathway [32], tight junction [32], bladder cancer [32] and amebiasis [32].