ATP1A3 and alternating hemiplegia of childhood: To date, 59 different de novo missense mutations in ATP1A3 have been identified in AHC patients, including three affecting the isoleucine at position 810: I810F, I810N, and I810S (Heinzen et al., 2014; Panagiotakaki et al., 2015; Rosewich, Ohlenbusch et al., 2014; Sasaki et al., 2014; Ulate-Campos et al., 2014; Viollet et al., 2015; Yang et al., 2014).