To investigate whether Myk/+ mice exhibit learning and memory deficits resembling the cognitive impairments of patients with ATP1A3-related disorders (Barbano et al., 2012; Paciorkowski et al., 2015, 2010; Sweney et al., 2009), we subjected them to a range of behavioral tests that interrogate various cognitive domains. This evidence concerns the gene ATP1A3 and Cognitive impairment.