Together, these data suggest differences in the expression of transcripts associated with transcription factors such as AR, ERG or HES6 (Lamb et al., 2014) within certain prostate cancer subtypes, as well as certain changes in the expression of specific transcripts such as NKX3-1 upregulation (iCluster 5), CDH1-up (iCluster 3), cyclin-D1 down (iCluster 2) and TP53 downregulation (iCluster 3), consistent with previous findings (Markert et al., 2011). The gene discussed is HES6; the disease is prostate cancer.