PIK3R1 and prostate carcinoma: Similarly, analysis of 101 samples studied by Tomlins et al. [21] found that expression of PIK3R1 was reduced by −3.266 fold (p=5.87E-7) in prostate carcinoma relative to normal tissue, and in this dataset PIK3R1 was in the top 1% of under-expressed genes (Figure 5B) (data was generated using Oncomine [30]).