To define further the role of N-CoR in the regulation of Flt3+/CD34+-based stem cell phenotype in promyelocytic and monocytic AML, we took advantage of genistein, a soy extract that effectively restored the native N-CoR conformation and function in promyelocytic and monocytic AML (7–9). This evidence concerns the gene FLT3 and acute myeloid leukemia.