These findings suggested that N-CoR-mediated transcriptional repression of stem cell genes like Flt3 might be crucial for the suppression of self-renewal potential of hematopoietic cells during their commitment and differentiation to cells of myeloid lineage and that de-repression of Flt3 due to N-CoR misfolding may contribute to formation of leukemia-initiating cells (LICs) or leukemic stem cells (LSCs) through the ectopic reactivation of self-renewal potentials in relatively matured cells. Here, NCOR1 is linked to leukemia.