CD34 and acute myeloid leukemia: Owing to the misfolding and premature loss of N-CoR protein in promyelocytic and monocytic AML cells, the repressive control of N-CoR on Flt3 will be lost, which would lead to up-regulation of Flt3 and eventual reactivation of the Flt3+/CD34+-based stem cell phenotype in promyelocytic and monocytic AML.