Next, to investigate the role of N-CoR in the suppression of stem cell phenotype defined by Flt3+/CD34+, monocytic AML-derived THP-1 cells were transfected with Flag-tagged N-CoR expression plasmid or control vector and any change in CD34 positivity was determined by FACS. The gene discussed is FLT3; the disease is acute myeloid leukemia.