NCOR1 and acute myeloid leukemia: The suppression of this self-renewal and growth potentials by N-CoR might be a net outcome of N-CoR-mediated transcriptional repression of stem cell self-renewal genes like Flt3. If true, then loss of N-CoR function due to misfolding may lead to de-repression of stem cell self-renewal genes like Flt3 and eventual reactivation of stem cell phenotypes in promyelocytic and monocytic AML.