Therefore, to test if misfolding of N-CoR leads to the unmasking of stem cell-like phenotypes in promyelocytic and monocytic AML, the relative “stemness” (CD34+/Flt3+ phenotype) of promyelocytic and monocytic AML-derived cells was compared with that of non-promyelocytic–monocytic AML cells in which N-CoR is not misfolded. Here, NCOR1 is linked to acute myeloid leukemia.