Therefore, to test if misfolding of N-CoR leads to the unmasking of stem cell-like phenotypes in promyelocytic and monocytic AML, the relative “stemness” (CD34+/Flt3+ phenotype) of promyelocytic and monocytic AML-derived cells was compared with that of non-promyelocytic–monocytic AML cells in which N-CoR is not misfolded. The gene discussed is CD34; the disease is acute myeloid leukemia.