FLT3 and acute myeloid leukemia: We have also demonstrated that Flt3, the cytokine receptor essential for the self-renewal of primitive hematopoietic cells (10, 11), is actively repressed by N-CoR and that misfolding and premature loss of N-CoR protein leads to the de-repression of Flt3 in promyelocytic and monocytic AML-derived primary and secondary leukemic cells (8).