FLT3 and acute myeloid leukemia: We have further shown that a natively folded N-CoR actively represses Flt3, the key regulator of the stem cell phenotype and self-renewal potentials in primitive hematopoietic cells, and that misfolding of N-CoR is directly linked to up-regulation of Flt3 in promyelocytic and monocytic AML cells (8).