Whether the altered cellular homeostasis in cancer cells is called addiction or amnesia, studies suggest that the reversal of Plk1 addiction is sufficient for inducing selective cellular senescence or apoptosis in oncogenic RAS- or inactivated TP53-containing cancer cells (Luo et al. 2009a; Sur et al. 2009) (Fig. 2). The gene discussed is TP53; the disease is cancer.