A variety of aberrant phenotypes observed during corticogenesis (defects in migration, axon growth, and dendrite arborization) and in vitro analyses (defects in spine morphology) may be the consequence of the impaired splicing events in affected neurons and could account for the emergence of the various clinical symptoms of ASD and other disorders such as ADHD, ID, epilepsy, and schizophrenia, where RBFOX1 gene abnormalities are involved. This evidence concerns the gene RBFOX1 and attention deficit-hyperactivity disorder.