Moreover, the manifestations of enteropathy in IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome) patients (who lack functional Foxp3 Treg), which are often considered to provide support for a role for Foxp3+ Tregs in the prevention of IBD, clearly differ from those in IBD (41). This evidence concerns the gene FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.