Besides the enhanced release of tumor antigens through induction of cancer cell death, chemotherapeutics, including oxaliplatin, doxorubicin, mitoxantrone, and melphalan, induce HMGB1 release and calreticulin translocation in cancer cells, facilitating antigen uptake by DCs and subsequent T cell stimulation (145–147). The gene discussed is HMGB1; the disease is cancer.