Currently, there are several anti-CD40 antibodies such as CP-870,893, dacetuzumab, and lucatumumab either as stand-alone treatments or in various combinations under investigation, such as a phase 1A/II study (NTC00670592) of patients with advanced non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma (HL), which demonstrated a modest lucatumumab activity (109). Here, CD40 is linked to Hodgkins lymphoma.