The importance of TLR4 activation via danger signals can be seen in patients suffering from breast cancer, head and neck squamous cell carcinomas (HNSCC), or colorectal cancer carrying a loss of function single-nucleotide polymorphism (SNP) in the Tlr-4 locus that have a predicted worsened outcome after immunogenic CT with anthracyclines or oxaliplatin (51, 52). Here, TLR4 is linked to breast cancer.