Dewan and colleagues reported an abscopal effect in breast (TSA) and colon cancer (MCA38) models: An increased frequency of CD4+ and CD8+ tumor-infiltrating lymphocytes along with tumor-specific IFN-γ production was observed after a combined administration of anti-CTLA-4 mAb (9H10) and fractionated (3 × 8 Gy or 5 × 6 Gy fractions in consecutive days), but not single-dose RT with 20 Gy. This evidence concerns the gene CD4 and neoplasm.