Oxidation of the heme group on sGC leading to its dissociation from the enzyme and the generation of NO-insensitive sGC has been reported in experimental models of hypertension and hyperlipidemia, as well as in patients with cardiovascular diseases and DM2 (Gladwin, 2006; Stasch et al., 2006, 2011). The gene discussed is SGCB; the disease is hyperlipidemia.