Transgenic mice that overexpress Dyrk1A exhibit brain developmental defects and behavioral alterations similar to those found in DS patients and in murine models with partial MMU16 trisomies, such as the Ts65Dn mouse, which carries extra copies of several genes, including the Dyrk1A gene (De la Torre et al., 2014). This evidence concerns the gene DYRK1A and Dravet syndrome.