S100B and major depressive disorder: Brain derived neurotrophic factor (BDNF), S100B and neuron specific enolase (NSE) are among the most studied biomarkers in affective disorders, in particular major depressive disorder (Schroeter et al., 2002; Hetzel et al., 2005; Andreazza et al., 2007; Schroeter and Steiner, 2009; Kalia and Silva, 2015).