The variant MTHFR C677T, known to be associated with increased levels of HCY (Kang et al., 1988; Li et al., 2003) is more frequent among ALS patients (Kühnlein et al., 2011), however an Italian population study found no association (Ricci et al., 2012). The gene discussed is MTHFR; the disease is amyotrophic lateral sclerosis.