PDGFRA and ischemic stroke: Since both TBI and ischemic stroke share the common pathophysiologic mechanisms of loss of BBB control and the development of cerebral edema (Bouma et al., 1991; Marion et al., 1991; Zauner et al., 1996; Bramlett and Dietrich, 2004; Lescot et al., 2010), we hypothesized that, as is the case with ischemic stroke, PDGFRα signaling might also play a role in TBI.