While it has not been studied in newborn granule cells in the model of epilepsy, a study performed in an animal model of schizophrenia and bipolar disorder showed that both GluR1 and GluR2 immunoreactivities were substantially down-regulated in 3–4 week old dentate granule cells (Hagihara et al., 2011). Here, GRIA1 is linked to epilepsy.