NOS2 and cancer: In mouse skin with TPA-induced acute inflammation (mouse ear edema) and 19 weeks TPA-induced tumor promotion in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mouse skin, XNT suppressed cancer and inflammatory biomarkers including ODC, COX-2 and iNOS expression through MAPKs, NF-kB and or protein kinase B (Akt) [26].