Gene expression microarray analysis of FOXP1-overexpressing human B cells has produced similar findings showing regulation of the immune response and leukocyte activation signatures,39 and thus FOXP1 appears to be a broad controller of multiple B-cell:T-cell interaction molecules in both normal and malignant B cells.4, 10 FOXP1-dependent targets in GCB-DLBCL cell lines exhibited enrichment for distinct GO terms related to neuron components and regulation of metabolic processes. This evidence concerns the gene FOXP1 and diffuse large B-cell lymphoma.