FOXP1S expression contributes to pathogenic MHC II downregulation in DLBCL and may also be important for its normal role in B cells where FOXP1S is induced during B-cell activation/maturation.9 Targeting the FOXP1 pathway may enable the upregulation of classical and non-classical MHC II genes to overcome tumor-immune evasion.15, 59 We propose that FOXP1 may act together with the CIITA complex to regulate expression of MHC II genes. Here, CIITA is linked to diffuse large B-cell lymphoma.