However, low transcript levels of HLA-DRB and HLA-DQA1 (<20%) and high levels of MYC (>80%), determined using a quantitative nuclease-protection assay, were predictors of poor prognosis in 116  R-CHOP-treated DLBCL.51 Interestingly, FOXP1 may functionally link these two observations, as repression of microRNA-34a by MYC has been reported to enable high-level FOXP1 protein expression,52 which may then functionally repress MHC II transcription. The gene discussed is HLA-DRB1; the disease is diffuse large B-cell lymphoma.