We previously demonstrated that reciprocal frequency expression of FOXP1 (⩾70%) and HIP1R (⩽10%), the FOXP1hiHIP1Rlo phenotype, in this DLBCL series was more clinically relevant than either marker alone and hypothesized that this might represent a preferential measure of FOXP1S transcriptional activity.7 Interestingly, patients with reciprocal patterns of FOXP1 and HIP1R expression exhibited significantly reduced intensity (P=0.0405) and frequency (P=0.0300) of HLA-DRA expression (Figure 6c). The gene discussed is HIP1R; the disease is diffuse large B-cell lymphoma.