FOXP1 and diffuse large B-cell lymphoma: One mechanism being the ability of FOXP1 to potentiate Wnt/β-catenin signaling in DLBCL.6 For example, in an R-CHOP-treated cohort of DLBCL cases (n=233), higher than average FOXP1 expression correlated with significantly inferior overall survival (OS; P=0.0113).7 Activation-induced short isoforms (FOXP1S)8 and genetic rearrangements of FOXP1 leading to truncated FOXP1 isoforms9 may also have important biological roles, for example, by altering or interfering with the normal function of the full-length FOXP1 (FOXP1L) protein or by acquiring novel functions.