The analysis of individual FOXP1 target genes identifies several direct targets, in addition to HIP1R,7 whose expression contributes to the GCB-DLBCL COO signature, including LPP,33VNN233 and NEIL1. 34 This is consistent with data from Sagardoy et al.46 demonstrating that FOXP1 regulates genes involved in the GC reaction and that downregulation of FOXP1 is required for GCB function. This evidence concerns the gene HIP1R and diffuse large B-cell lymphoma.