Nahid et al.9 used the SOMAscan proteomics method and found differential changes in serum extracellular matrix protein 1, the tyrosine-protein kinase Yes, insulin-like growth factor-binding protein 1, cathepsin Z, coagulation factor V and serum amyloid A proteins between TB patients with 2 months treatment and untreated TB patients. The gene discussed is CTSZ; the disease is tuberculosis.