PHGDH and neoplasm: Both PHGDH and PSAT1 contribute to serine/ glycine biosynthesis, which plays an important role in supporting nucleotide synthesis in rapidly proliferating cells (Jain et al., 2012; Labuschagne et al., 2014), and recent publications indicate that high expression of PHGDH in tumor tissue is required for cell growth in epithelial malignancies (Locasale et al., 2011; Possemato et al., 2011).