MSLN and neoplasm: More than 20 self-antigens have been described in EOC, including several membrane-bound proteins with limited processing and presentation (e.g., ERBB2, MUC16, and Mesothelin) [12] and others that are significantly expressed in normal tissue (e.g., Mesothelin, Cyclin I, FOLR1, WT1, and MUC1)., implying not only tolerance by the peripheral T-cell repertoire, but also the risk of immunogenic toxicity (on-target/off-tumor toxicity) in the case of an effective T-cell response.