In some cancers including multiple myeloma, breast cancer, prostate cancer, and renal carcinoma hypercalcemia may be induced by production of osteoclast-activating factors such as tumor necrosis factor alpha, interleukine 6, and receptor activator of nuclear factor-κB ligand (RANKL) [8, 9]. This evidence concerns the gene TNFSF11 and Familial prostate cancer.