Especially the simultaneous inhibition of the MAPK and the PI3K/mTOR pathways, which are mutated in a multiplicity of human cancers, yielded promising results in various in vitro and in vivo studies [3, 14, 23, 46, 54, 64], since these signaling cascades are known to influence proliferation, cell growth, survival and resistance to chemotherapeutics and IR [13, 50, 60]. Here, MTOR is linked to cancer.