EIF4EBP1 and neoplasm: As expected and in accordance with published results for different tumor entities, the treatment with AZD6244 and NVP-BEZ235 alone resulted in inhibition of the MAPK and PI3K/mTOR signaling cascade, respectively, as confirmed by reduced expression of p-Erk, p-Akt, p-S6 and p-4E-BP1 (Fig. 2).