Although, there is evidence that simultaneous treatment with the MEK inhibitor AZD6244 and the PI3K/mTOR inhibitor NVP-BEZ235 causes synergistic effects on tumor cell proliferation and induction of apoptosis [24, 26, 53, 56, 59], little is known about the radiation response of tumor cells after simultaneous inhibition of the MAPK and the PI3K/mTOR pathways. This evidence concerns the gene MTOR and neoplasm.