NLGN3 and central nervous system cancer: Using biochemical approaches to identify the factor(s) mediating this effect of neuronal stimulation on glioma cell proliferation, Venkatesh et al concluded that the effect was mediated by a secreted protein between 10 and 100 kDa and mass spectrometry and functional investigations identified Neuroligin 3 as a major regulator (Venkatesh et al., 2015).