On this basis, Anoctamin-1 gene (ANO1, also termed TMEM16A, ORAOV2, DOG1, TAOS2 and FLJ10261), encoding a calcium-activated chloride channel, has emerged as a strong candidate to drive 11q13 amplification in HNSCC by providing growth advantage to tumours and favouring metastatic dissemination7. Here, ANO1 is linked to neoplasm.