To gain insight into the biological pathways involved in pancreatic cancer pathogenesis stratified by the median of RPL15 expression, Gene Set Enrichment Analysis (GSEA) performed in GSE28735 dataset showed that “Gruetamann_Pancreatic_Cancer_UP” and “Liao_Metastasis” pathway were enriched in patients with RPL15-lower expression versus patients with RPL15-higher expression (Figure 4A-4B). The gene discussed is RPL15; the disease is familial pancreatic carcinoma.