Furthermore we analyzed the effect of miR-149 overexpression in two HCC cell lines, HepG2 and MHCC97H, on the expression of PPM1F and other putative target genes (GIT1, SP1, FOXM1) previously reported by other groups to promote migration and invasion in other cancer cell lines [9, 10, 14]. The gene discussed is PPM1F; the disease is cancer.