With respect to the germline variation of PC, multiple genes including BRCA2, PALB2, ATM, the ABO loci, NR5A2, CLPTM1L-TERT, BACH1, DAB2, and FAM19A5, have been shown to be associated with the progression of PC [1, 5–9]. This evidence concerns the gene NR5A2 and pachyonychia congenita.