Finally, the U2-dependent spliceosome proteins, SF3B1, U2AF35, U2AF65, and PRRF40B, are significantly mutated in solid tumors of lung adenocarcinomas [15], while mutations in SF3B1 have been associated with breast cancer, uveal melanoma, and PC [16–18]. This evidence concerns the gene U2AF2 and pachyonychia congenita.