BIN1 and cancer: For example, the abnormal expression of SR family proteins (e.g., SRSF1 and SRSF3) in various human tumors was found to affect the alternative splicing of cancer-related genes, such as RON, BIN1, MNK2, S6K1, KLF6, FoxM1 and HIPK2, thereby creating protein isoforms that could contribute to the proliferation, avoidance of apoptosis, cell cycle modulation, or signal transduction of tumor cells [26–30].