EIF4H and malignant colon neoplasm: The 27 KDa eIF4H isoform was also found to be overexpressed in human colorectal and esophagus cancer tissues [26], where the silencing of only the long eIF4H isoform inhibited proliferation and induced apoptosis of colon cancer cells, suggesting that this isoform specifically contributes to cell proliferation and carcinogenesis.