Interestingly, we found that mPGES1 was significantly up-regulated in all COX2-overexpressing colorectal carcinoma cell lines tested (an example of HT29 and SW480ADH is shown in Fig. 5A and for Caco2-COX2 a 14 ± 3 fold increase of PTGES was observed when comparing to EV cells). Here, PTGS2 is linked to colorectal carcinoma.