IRES-driven translation has been demonstrated for many important cancer genes, the majority being oncogenes, e.g. Vascular Endothelial Growth Factor (VEGF) [12, 13] c-MYC [14, 15], BCL2 [16], and XIAP [17], but with notable examples in the tumor suppressor class with the TP53 and p27 genes [18–20]. The gene discussed is MYC; the disease is cancer.