After restoration of miR-652, the acidity-treated pancreatic cancer cells (PANC-1-A and BxPC-3-A, incubated in pH 6.4 value medium for 72 h) demonstrated a dramatic MET (mesenchymal to epithelial transition) presenting with significant decreased cell motility, invasion ability (Fig. 3A), upregulated E-cadherin and downregulated N-cadherin, MMP-2 and ZEB1 (Fig. 3B). Here, CDH2 is linked to familial pancreatic carcinoma.