Treatment with 0.02 mg/kg tunicamycin for 21 days resulted in significant decrease of EGFR, HER2 and HER3 in tumor samples from MCF-7/HER2 xenograft, demonstrating that the dose of 0.02 mg/kg tunicamycin abrogated the N-glycosylation process in tumor. The gene discussed is EGFR; the disease is neoplasm.