Nonetheless, the percent and intensity of breast cancer cells positive for PR protein by immunohistochemistry is positively correlated with time to recurrence in both tamoxifen and anastrozole treated patients, and Luminal A type breast cancers containing more than 20 % PR positive cells have a better prognosis than those with less than 20 %, independent of endocrine therapy [59]. Here, PGR is linked to breast cancer.