EGFR and squamous cell lung carcinoma: Interestingly, it was discovered that E-cadherin can regulate EGFR in HNSCC cell lines [53] and that CELF1 can regulate E- cadherin protein levels in lung squamous cell carcinoma cells [30]; thus, CELF1 may control cell survival through coordinated regulation of EGFR, E-cadherin and cMYC expression in OHKC-CELF1 cells.