In contrast, local induction of GILZ expression by injection of GILZ-adeno-associated virus (GILZ-AAV) into the joints inhibited disease development in the CIA model [64], leading to the conclusion that endogenous GILZ had no effect on inflammatory effector pathways in arthritis, whereas the administration of exogenous GILZ might have some therapeutic value. This evidence concerns the gene TSC22D3 and arthritic joint disease.