TSC22D3 and Arthritis: Contradictory to a previous report of exacerbation of CIA by siRNA-mediated GILZ silencing [63], GILZ knockout in C57BL/6 mice influenced neither disease severity nor the therapeutic efficacy of GCs in several models, including antigen-induced arthritis (AIA), K/BxN serum-transfer arthritis, CIA, and endotoxemia [64].