CCND3 and breast cancer: Further supporting the post-translational nature of this effect, cycloheximide treatment efficiently depleted BC cells of proteins with a comparable short half-life (e.g. cyclin D3) but only modestly affected SOX2, indicating that SOX2 protein has a comparably longer half-life in BC (Figure 6F) and a complete inhibition of SOX2 protein could not be achieved as fast through translational repression.