The pre-LSCs of many leukemias exhibit multilineage potential and differentiation, as mentioned above, pre-LSC CML associated with BCR-ABL fusion exhibit multilineage differentiation whereby mature granulocytes, monocytes, erythrocytes, platelets and B lymphocytes are all part of the malignant clone (Figure 7A). Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.